EC Number | Cloned (Comment) | Organism |
---|---|---|
1.14.14.139 | expression analysis, transcription factor G protein pathway suppressor 2, GPS2, affects CYP8B1 expression, mediated by direct interactions with LRH-1 and HNF4alpha, while the small heterodimer partner, SHP, does not affect the expression, Identification of a functional FXR response element in the human CYP8B1 promoter, regulation mechanism, overview | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.139 | 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | activation of farnesoid X receptor FXR initiates a feedback regulatory loop via induction of small heterodimer partner, SHP, which suppresses liver receptor homolog 1, LRH-1, and HNF4alpha dependent expression of sterol 12alpha hydroxylase, CYP8B1, overview | 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.139 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.139 | 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
1.14.14.139 | 5beta-cholestan-3alpha,7alpha-diol + [reduced NADPH-hemoprotein reductase] + O2 | activation of farnesoid X receptor FXR initiates a feedback regulatory loop via induction of small heterodimer partner, SHP, which suppresses liver receptor homolog 1, LRH-1, and HNF4alpha dependent expression of sterol 12alpha hydroxylase, CYP8B1, overview | Homo sapiens | 5beta-cholestan-3alpha,7alpha,12alpha-triol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.139 | CYP8B1 | - |
Homo sapiens |
1.14.14.139 | sterol 12alpha hydroxylase | - |
Homo sapiens |